Gene therapy

Gene therapy

Of course treating erectile dysfunction you can take Viagra or cialis online (, but there is a new and very progressive ED therapy meaning that genes producing products needed for a proper function will be delivered into the penile tissue. These products are known as proteins and they can improve erectile function. Still this is experimental model, which is applied in animals only and it will take some time to carry on human studies and approve it officially.

What do we know about ED mechanism?

It is well known that erection happens when blood fills in the penis. All the processes connected with the expected reaction are possible thanks to correspondent nerves and nitric oxide mostly. If something prevents these regulators from fulfilling their functions, the erectile dysfunction occurs and a man is not able to have and maintain an erection.

If a man is not able to get erection occasionally – it is normal. Usually such a failure does not mean a serious health problem. Though when this reaction is frequent, then it should be regarded as a bad sign and needs to be investigated. Perhaps the reason is just stress or tiredness, but also it can be an early symptom of a deviation that demands medical intervention. In any case you should talk to a doctor and get a professional consultation if you have frequent erectile dysfunction. If a doctor discovers a psychological cause, you are expected to change your life style. But if there is a physical reason, you should turn to the correspondent specialist and start treatment. Such health conditions as diabetes, overweight, nerve damage, heart disease can lead to ED. Even healthy men can suffer from impotence due to their age. This deviation happens more often with older men.

Treatments with gene therapy

In general gene therapy is developed to treat or prevent various health conditions. The principle of its work includes influencing on the genes, which are responsible for the treated disease. Thus the scientists try removing a faulty gene replacing it with a new proper one. Still this therapy is experimental, unfortunately, but it brings hope. It is safe and effective method allowing to get rid of the disease.

Speaking about ED treatment, more often the research is concentrated on nitric oxide. We know that all remedies taken by mouth also target nitric oxide, the gene therapy does the same. When the reason of ED is damaged nerves happened because of diabetes or Parkinson’s disease, gene therapy is focused on restoring the function of that damaged nerves providing the steady and lasting erections. The animal studies demonstrated positive results in both cases.

There are two ways of delivery: viral and nonviral. In other words the genes can be delivered to a patient’s DNA with use of virus or without it, the last technic is safer though less efficient as the first one.

The oral ED treatment is very effective and comparatively safe while gene therapy has its own advantages. First of all the medications do not impact all patients and have a range of side effects and precautions. So we cannot say that tabs are a safe option for all men suffering impotence. For example those who take nitrate heart medications or have heart disease cannot use most pills offered at the market, while gene therapies is safe for all men. The process of delivery is very simple – just an injection two times a year.

But until all researches and approvals last, you can buy levitra in Australia and treat ED.

Cialis vs. Levitra vs. Viagra: How Each Stacks Up

Cialis vs. Levitra vs. ViagraThree types of pills – what`s the difference?

All three drugs belong to one and the same enzyme – PDE5. That is, it turns out that the effect is the same, but Cialis has a difference structure. In practice, Cialis structure allows it to act much longer, in contrast, from its counterparts. The fastest uptake belongs to Levitra. It is necessary to mention the fact that in itself Sildenafil, Cialis, Levitra does not cause increased libido and are not psychotropic medications. It turns out that if a man is convinced in his sexual power, libido comes to him. All of these medications have proven many times its own effectiveness in practice and have the approval of official medicine with a certain set of contraindications.

How Do They Work?

These products are ideal for the treatment of impotence; they are different from simple medicines, and have a long impact. All ingredients are natural, sexual function is able to be restored within 2-3 months after treatment. They have in common reason for admission in order to strengthen an erection and be sure to conduct a full sexual intercourse. These means selectively dilates blood vessels of cavernous bodies of the penis, increasing its blood supply, increasing in size and compacted. Both have a convenient dosage form – pills, have many generics.

  • Tablets should be taken before sexual intercourse in advance.
  • The collapse of the drugs takes place with the help of enzymes produced by the liver, therefore, in diseases of the liver with impaired function of taking such pills is dangerous because of overdose or side effects.
  • They cannot be taken with medications that are commonly used by patients suffering from ischemic heart disease (nitrates short and long-acting). Joint reception can cause a sharp decrease in blood pressure and lead to life-threatening figures. These pills have other general contraindications to the use of:
  • violation of the structure of the penis;
  • presence of sharp fluctuations in blood pressure;
  • co-administration of Indinavir, erythromycin (co-administration enhances PDE5 inhibitor concentration in the blood of 56 to 210%), which could be dangerous.

How and When to Get

All three drugs have a similar mechanism of action, but they differ in time efficiency. Cialis has lasting effect on the body – up to one and a half a day. Viagra has the shortest exposure time – up to 5 hours of reaction. Levitra acts immediately, after 10 minutes after administration. Levitra helps even those men who fail to Viagra. The minimum dose of the drug is assigned to 25 mg, average dose – 50 mg. Minimal doses is recommended for those who suffer from kidney and liver diseases.

Twelve-month clinical study in the US proved that patients with diabetes and not sensitive to Viagra, proved that Levitra with flexible doses gives a positive result. It increases the frequency of sexual intercourse with mild to moderate erectile dysfunction. In this case side-effect is minimal compared to Cialis and Viagra. Cialis, for example, can be manifested with back pain. In addition there are some others effects:

  • Side effects:
  • back pain;
  • pain in the muscles and the cervical spine;
  • stomach pain;
  • runny nose.

As a rule, patients showed a temporary blurred vision, increased body temperature.

Correlation with other components

In the case of diabetes, as well as in the use of nitrate-containing medications (eg, for the treatment of diseases of the heart) before starting dose of tadalafil, you need to get medical advice. As previously emphasized, mixing Cialis with grapefruit or grapefruit juice may lead to adverse consequences. Thus, you should avoid eating any foods containing this fruit. If you are allergic to tadalafil or any of the ingredients contained in Cialis, it is better to avoid its use. In addition, in diseases of the liver, kidney or heart disease, diabetes, abnormal blood sugar, should not take Cialis without prescription.

What Is It Better To Do First: Weights Or Cardio?

What is it better to do first: weights or cardio?

If you are trying to guess which part of the training has to go first, here is the answer: the new studies have proven that cardio has eventually won.

Half an hour of aerobics performed in moderation will enrich you with higher levels of testosterone than doing the workout the opposite way. These data were introduced to the public by the edition titled Journal of Strength and Conditioning Research.

Is the debate finally over?

No. it really isn’t! The increasing of testosterone can not be considered the only one effect that appears to be after training. The researchers found the contradiction: aerobics also helps to release the enzyme that prevent the muscles from building up after the strength training.

The logically thinking man may think that the big amount of testosterone is awesome but the research hasn’t concluded yet that the significant rise of this hormone leads to gaining strength afterwards. That thought was initially expressed by Marc Perry (who is the founder of BuiltLean and a current trainer) when giving the interview to Men’s Health. He chiefly recommends to the ones who can’t separate cardio and weights trainings, to start with weights to gain more strength, muscle mass and power of course. He finds it to be especially true when:

  • Your type of cardio exercise isn’t cycling, which was performed by the participants. Such cardio practices as swimming, rowing or jogging have a tendency to cause more tiredness than you shape may hold.
  • By introducing interval training, your cardio is made to past mild effort. If you do it initially, you won’t be able to do any lifts at all.
  • You work with big weights or your training generally involves complex steps (for instance, Olympic weights). If you start from the treadmill, you will be completely worn out to do the complex steps in the right way.

But at the same time Perry notices that there are some cases when cardio necessarily has to come first in your training. They include the following situations:

  • You just enjoy it more. It will assist you in achieving the goal. Perry notes, that if a person hates lifting weights first, he just won’t do so.
  • Your age. If you are an older sportsman, you need to have a good warmup before you start the actual training. It will just be more sensible to behave this way.
  • You are on the way of building up the overall endurance. It would be great if you could hold the chief goal in your head and didn’t get distracted.